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Got Psoriasis?

    • 1955 posts
    April 3, 2014 1:17:29 AM PDT

    Question

    Skin Disease

    Is this Disease Contagious?

    Yes - Always --> No - Never --> Yes - Only with extensive touching

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    Scroll down for answer

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    Embedded image permalink

    The pictured skin condition of psoriasis isn't contagious, but awareness is. It's a good thing.
    If we can learn the precise pathophysiology of the immune mediated disease psoriasis we can aim to develop therapies to treat the cause of the disease.

    This webpage might be useful for anyone seeking to learn more about psoriasis. Please leave your comments and feedback so I can improve the page. Thank you kindly.

    Cause of Psoriasis, better known as "causes of Psoriasis".

    This website claims that if we better understand psoriasis, we might be able to design drugs to fix the "broken" parts of the system. For example, if I membrane protein has the wrong amino acid and the protein does its job too well, never stopping, we could try to make a drug that blocks that protein. The human body is composed of numerous biochemical systems. In psoriasis, it isn't simply one membrane protein that is overreacting... Psoriasis isn't one disease.... There are probably multiple different "changes" in any of thousands of proteins that lead to the disease. Alone, any single mutation has not been shown to cause psoriasis like some other disease. However, it is suspected that there is a combination of mutations variations, and environmental alterations that results in the manifestation of an overactive immune system with flaking of the skin as defined by the term Psoriasis.

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    Fitzpatrick's Color Atlas and Synopsis of Clinical Dermatology: Sixth Edition (Fitzpatrick's Color Atlas & Synopsis of Clinical Dermatology)
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    Prediction about BlockBuster Psoriasis Med Approval.
    Have you seen the Phase II article by NEJM on #Brodalumab, some other hopefuls are #ixekizumab http://www.nejm.org/doi/full/10.1056/NEJMoa1109017

    Brodalumab will be approved by May 1, 2014 for #Psoriasis

    Links to Psoriasis websites:

    1. http://www.psoriasis.org

    2. http://www.psoriasis.com

    3. http://www.rwjuh.edu/health_information/adult_derm_psoria.html

    4. http://www.ncbi.nlm.nih.gov/pubmed/22278173

    5. http://umm.edu/health/medical/altmed/condition/psoriasis

    6. http://www.med.nyu.edu/sacu/clinics/psoriasis.html

    7. http://www.nejm.org/doi/full/10.1056/NEJMra0804595

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    This post was edited by DrSocial Admin at June 7, 2015 9:44:18 AM PDT
    • 1955 posts
    July 9, 2014 3:45:26 PM PDT
    Sometimes there is loss of efficacy of biologic medications, aka, they stop working.

    One of the reasons that this occurs is secondary to neutralizing anti-drug antibodies.. Neutralizing means that the patient makes antibodies against the antigen binding site of the monoclonal antibodies.

    Here is a nice review article that I was privileged to be a first co-author on.

    Antidrug Antibodies in Psoriasis, a Systematic Review
    http://onlinelibrary.wiley.com/doi/10.1111/bjd.12654/abstract
    • 445 posts
    July 11, 2014 11:12:42 AM PDT

    For those who are interested in the psoriasis topic, please check this additional article of our forum:

    http://drsocial.org/forums/topic/186/psoriasis-and-biologics

    • 445 posts
    March 28, 2015 4:56:01 AM PDT

    Dear reader,

    if you are looking for any information related to psoriasis you may want to read the following forum posts:

    Linear Pustular Psoriasis - Graphic Anatomy

    Psoriasis

    My scalp itches like crazy, but only sometimes. Why?

    Psoriasis Clinical Studies

    Not suppurative arthritis, then what?

    Breakout on palms of hands

    Antidrug Antibodies in Psoriasis: A Systematic Review

    Psoriasis and Biologics

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