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Inflammatory Breast Cancer Definition

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    September 2, 2016 8:43:17 PM PDT

    Inflammatory Breast Cancer is not a Distinct Histologic Subtype


    Inflammatory Breast Carcinoma (IBC) is a clinical diagnosis that is confirmed by the pathologic identification of invasive carcinoma.[1] The invasive carcinoma is not an inflammatory histology, but could be an invasive ductal carcinoma, invasive lobular carcinoma, or another histologic subtype. Page five of the College of American Pathologists (CAP) Invasive Breast Cancer Protocol lists the histologic subtypes of breast cancer, and it does not include IBC as a distinct histologic subtype.[2] The National Comprehensive Cancer Network (NCCN) guidelines endorse the CAP protocol as well as the International Classification of Diseases in Oncology Third Edition (ICDO-3rd).[3, 4] Both the NCCN guidelines and the ICDO-3rd list IBC as a specific histologic subtype of breast cancer.

    In conclusion, the NCCN guidelines, the ICDO-3rd, and the National Cancer Data Base need to have IBC removed from their lists of breast cancer histologic subtypes.



    1. Dawood S, Merajver SD, Viens P, et al. International expert panel on inflammatory breast cancer: consensus statement for standardized diagnosis and treatment. Ann Oncol 2011;22(3):515‐23.
    2. Pathologists CoA. Protocol for the Examination of Specimens From Patients With Invasive Carcinoma of the Breast. In; 2013, 1‐37.
    3. National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: breast cancer. 2015 ( In.
    4. Fritz, April, et al. International classification of diseases for oncology. No. Ed. 3. World Health Organization, 2000.

    1.      Title


    Inflammatory breast cancer is not a distinct histologic subtype



    Four word title:   NCDB Coding of IBC



    2.  Names, academic degrees, and affiliations of all authors;


    Brett Snodgrass, M.D.

    Clinical Management Consultant DrSocial Ltd.


    3.  a word count for text only (ie, not including the title, acknowledgments, references).




    4.  Corresponding Author

    Identify a corresponding author and include that author's address, telephone numbers, and email address on the title page


    Brett Snodgrass, M.D.

    468 N Camden Drive Suite 200

    Beverly Hills, California, 90210

    Telephone:    1 (916) 893-1722

    Fax:              1 (877) 991-6435




    5.  Conflicts of interest



    This post was edited by Brett Snodgrass at September 2, 2016 8:55:59 PM PDT